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DIFFERENT EFFECTS AND USES OF THC AND CBD
Let´s look at THC vs CBD. The two most known and commented cannabinoids present in cannabis are THC and CBD. Both interact with the human body by linking to different cannabinoid receptors that exist in the body and brain. Although these receptors are normally activated to create homeostasis in the body, cannabinoids such as THC and CBD cause and stimulate different behaviors.
THC (tetrahydrocannabinol) is the main psychoactive component of cannabis and works by linking CB1 and CB2 receptors in the human brain. CB1 receptors exist mainly in the central nervous system, managing the release of neurotransmitters. CB2 receptors, on the other hand, live in the immune system and are responsible for regulating bodily functions. It is said that CB1 receptors influence pleasure, appetite, memory and concentration, and the CB2 receptor moderates pain sensations and may be responsible for homeostasis in parts of the body such as the kidney and liver.
CBD on the other hand, interacts with receivers like the GPR55 or the 5-HT1A. It is not psychoactive, although it works in many ways with THC to contribute to the effect of cannabis. In fact, it counteracts the effects of THC in several aspects, so its proportion is important to determine the sensation produced by cannabis. CBD reduces the feeling of anxiety characteristically caused by THC, and has antipsychotic properties that balance the stronger effects of the buzz. In addition, it is associated with wakefulness and energy, for that reason, it is also complemented with THC.
THERAPEUTIC EFFECTS OF TETRAHYDROCANABINOL (THC)
THC or delta-9-tetrahydrocannabinol (Δ9-THC) has an analgesic, antispasmodic effect and allows relaxation of the senses. Also known as an antagonist of several cannabinoids such as CBD, which reduces the psychoactive effect of THC.
By listing the therapeutic effects, which we found in THC, we obtained:
Currently, there are numerous investigations focused on the treatment of cancer with THC (and other cannabinoids), which have shown antitumor effects when tested in animals. Today, trials are being conducted with humans at universities in Israel and the United Kingdom. Until there is a greater reference of the trials in which it is analyzed in humans, oncological patients can use cannabinoid treatment in an adjuvant way to the usual treatment, relieving the typical adverse effects of chemotherapy such as nausea, vomiting, sleep deficit, or lack of appetite.
In addition, several studies have been conducted on the therapeutic potential of THC in Alzheimer’s disease, where the neuroprotective potential for this type of patients is investigated, as well as the action in dementia states and as a treatment for agitation and aggression states.
Among the best known therapeutic approaches for THC is the treatment for multiple sclerosis and severe spasticity, which have a mouth spray with a proportion of THC | CBD 1: 1 for those who have not had results with other types of anti-spastic treatments.
THERAPEUTIC EFFECTS OF CANNABIDIOL
Compared to the other cannabinoids, cannabidiol has gained much importance in the therapeutic field because it lacks the typical psychoactive properties of THC (it does not act through the brain CB1 receptors responsible for psychoactivity), and they are reduced when the CBD and THC as a whole.
In this way, similar amounts of CBD and THC (1: 1 ratio or even higher than THC) can be administered without the appearance of strong adverse effects due to high amounts of THC (such as psychoactive effect, tachycardia, anxiety attacks, others). Although much remains to be done about the properties of cannabidiol, there are several studies that have demonstrated its benefits from a clinical point of view.
Its most important therapeutic effects are given by its properties; Anxiolytics, analgesics, antimicrobial, anti-emetic, antitumor, antioxidant, anti-inflammatory, antipsychotic, immunomodulatory, antibacterial, neuroprotective, antirheumatic and sleep-inducing.
Although the benefits of cannabidiol are not completely known, there are studies that have demonstrated its benefits from a clinical point of view. For example, experts have revealed their relationship to the immune system. And it has been shown that, in some cell lines of the immune system, CBD has the ability to inhibit the production of some cytokines (IL-8, IL-10, TNF-D, IFNJ). These tests directly relate CBD with beneficial effects in inflammatory / autoimmune diseases. Thus, CBD has anti-inflammatory, analgesic, anxiolytic and antipsychotic properties. There are also studies that have linked cannabidiol with the relief of chronic pain or to treat epilepsy, improve the symptoms of multiple sclerosis, among other diseases that chronically affect the patient.
Other research has focused on the effects of cannabidiol on arthritis. Thus, a trial with mice showed that a treatment with CBD (both oral and intraperitoneal) managed to block the disease, thus paralyzing its progression. These effects are related to the immunosuppressive activity and the anti-inflammatory property of this cannabinoid.
In a disease such as cancer, CBD causes a sedative effect in most cases and inhibits the transmission of nerve signals associated with pain. It has been seen that CBD reduces the growth of human breast cancer cells in vitro and in vivo in mice, and reduces their invasiveness.
THC and CBD work well as a team
Finally, CBD and THC have different effects. Our recent knowledge of being able to differentiate between the two and experiment with alterations of the genetic strain means that cannabis can be more available and accessible: with the genetic varieties with lower THC content, cannabis can be administered to children and the elderly to obtain the medicinal properties of CBD, for example.
But both work exceptionally as a team, and so far, we are waiting for more research to be done on the effects of cannabis. The two cannabinoids play a fundamental role in both physical healing and general experience when used. THC and CBD probably work together to produce many of the medicinal and psychoactive effects we experience in ways we do not yet understand. Although there are fundamental differences in the way they function individually in the body, we are still discovering all the ways in which they can work together.
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